Actinin

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Actinin is a microfilament protein. α-Actinin is necessary for the attachment of actin filaments to the z-line membrane, in muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.

The non-sarcomeric α-actinins (ACTN1 and ACTN4) are widely expressed. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.

Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis.

[edit] Genes

• ACTN1, ACTN2, ACTN3, ACTN4

[edit] See also

• actin

[edit] External links

• MeSH Actinin

v • d • e Proteins of the cytoskeleton Microfilaments Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein Intermediate filaments type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B) Microtubules Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin Catenins Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin Nonhuman Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB) Other APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin