ACTR1A

From Wikipedia, the free encyclopedia

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

Identifiers

External IDs

OMIM: 605143 MGI: 1858964 HomoloGene: 21173

Gene ontology
Molecular Function:	• nucleotide binding • structural molecule activity • protein binding • ATP binding
Cellular Component:	• cytoplasm • cytoskeleton • dynactin complex
Biological Process:	• vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005736 (mRNA)
NP_005727 (protein)

XM_981021 (mRNA)
XP_986115 (protein)

Location

Chr 10: 104.23 - 104.25 Mb

Chr 19: 46.43 - 46.45 Mb

Pubmed search

[1]

[2]

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast), also known as ACTR1A, is a human gene.^[1]

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast).

[edit] Further reading

Clark SW, Meyer DI (1992). "Centractin is an actin homologue associated with the centrosome.". Nature 359 (6392): 246–50. doi:10.1038/359246a0. PMID 1356230.
Lees-Miller JP, Helfman DM, Schroer TA (1992). "A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility.". Nature 359 (6392): 244–6. doi:10.1038/359244a0. PMID 1528266.
Schafer DA, Gill SR, Cooper JA, et al. (1994). "Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin.". J. Cell Biol. 126 (2): 403–12. PMID 7518465.
Clark SW, Staub O, Clark IB, et al. (1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.". Mol. Biol. Cell 5 (12): 1301–10. PMID 7696711.
Waterman-Storer CM, Karki S, Holzbaur EL (1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1634–8. PMID 7878030.
Holleran EA, Tokito MK, Karki S, Holzbaur EL (1997). "Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles.". J. Cell Biol. 135 (6 Pt 2): 1815–29. PMID 8991093.
Faulkner NE, Vig B, Echeverri CJ, et al. (1998). "Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres.". Hum. Mol. Genet. 7 (4): 671–7. PMID 9499420.
Bingham JB, Schroer TA (1999). "Self-regulated polymerization of the actin-related protein Arp1.". Curr. Biol. 9 (4): 223–6. PMID 10074429.
Heimann K, Percival JM, Weinberger R, et al. (1999). "Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles.". J. Biol. Chem. 274 (16): 10743–50. PMID 10196146.
Clark IB, Meyer DI (2000). "Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase.". J. Cell. Sci. 112 ( Pt 20): 3507–18. PMID 10504299.
Saffery R, Irvine DV, Griffiths B, et al. (2000). "Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins.". Hum. Mol. Genet. 9 (2): 175–85. PMID 10607828.
Fouquet J, Kann M, Souès S, Melki R (2000). "ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis.". J. Cell. Sci. 113 ( Pt 5): 877–86. PMID 10671377.
Karki S, Tokito MK, Holzbaur EL (2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1.". J. Biol. Chem. 275 (7): 4834–9. PMID 10671518.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Holleran EA, Ligon LA, Tokito M, et al. (2001). "beta III spectrin binds to the Arp1 subunit of dynactin.". J. Biol. Chem. 276 (39): 36598–605. doi:10.1074/jbc.M104838200. PMID 11461920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Carew JA, Jackson AA, Bauer KA (2004). "ARP1 interacts with the 5' flanking region of the coagulation factor VII gene.". J. Thromb. Haemost. 1 (6): 1220–7. PMID 12871323.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.