ACTL6B

From Wikipedia, the free encyclopedia

Actin-like 6B

Identifiers

ACTL6B; ACTL6; BAF53B

External IDs

MGI: 1933548 HomoloGene: 81844

Gene ontology
Molecular Function:	• structural constituent of cytoskeleton • protein binding • ATP binding
Cellular Component:	• nucleus • SWI/SNF complex
Biological Process:	• establishment and/or maintenance of chromatin architecture

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016188 (mRNA)
NP_057272 (protein)

NM_031404 (mRNA)
NP_113581 (protein)

Location

Chr 7: 100.08 - 100.09 Mb

Chr 5: 137.78 - 137.8 Mb

Pubmed search

[1]

[2]

Actin-like 6B, also known as ACTL6B, is a human gene.^[1]

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACTL6B actin-like 6B.

[edit] Further reading

Schafer DA, Schroer TA (2000). "Actin-related proteins.". Annu. Rev. Cell Dev. Biol. 15: 341–63. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
Glöckner G, Scherer S, Schattevoy R, et al. (1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.". Genome Res. 8 (10): 1060–73. PMID 9799793.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.". Biosci. Biotechnol. Biochem. 63 (5): 917–23. PMID 10380635.
Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex.". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMID 12368262.
Kuroda Y, Oma Y, Nishimori K, et al. (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.". Biochem. Biophys. Res. Commun. 299 (2): 328–34. PMID 12437990.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Oma Y, Nishimori K, Harata M (2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP.". Biochem. Biophys. Res. Commun. 301 (2): 521–8. PMID 12565893.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.