ACTL6A

From Wikipedia, the free encyclopedia

Actin-like 6A

Identifiers

ACTL6A; ACTL6; BAF53A; MGC5382

External IDs

OMIM: 604958 MGI: 1861453 HomoloGene: 55811

Gene ontology
Molecular Function:	• chromatin binding • protein binding • ATP binding
Cellular Component:	• nucleus • plasma membrane • chromatin remodeling complex • NuA4 histone acetyltransferase complex
Biological Process:	• regulation of cell growth • chromatin remodeling • transcription • regulation of transcription, DNA-dependent • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004301 (mRNA)
NP_004292 (protein)

NM_019673 (mRNA)
NP_062647 (protein)

Location

Chr 3: 180.76 - 180.79 Mb

Chr 3: 32.9 - 32.92 Mb

Pubmed search

[1]

[2]

Actin-like 6A, also known as ACTL6A, is a human gene.^[1]

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACTL6A actin-like 6A.

[edit] Further reading

Schafer DA, Schroer TA (2000). "Actin-related proteins.". Annu. Rev. Cell Dev. Biol. 15: 341–63. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex.". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.
Zhao K, Wang W, Rando OJ, et al. (1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.". Cell 95 (5): 625–36. PMID 9845365.
Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.". Mol. Cell 3 (2): 247–53. PMID 10078207.
Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.". Biosci. Biotechnol. Biochem. 63 (5): 917–23. PMID 10380635.
Ikura T, Ogryzko VV, Grigoriev M, et al. (2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.". Cell 102 (4): 463–73. PMID 10966108.
Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMID 11078522.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Sung YH, Choi EY, Kwon H (2001). "Identification of a nuclear protein ArpN as a component of human SWI/SNF complex and its selective association with a subset of active genes.". Mol. Cells 11 (1): 75–81. PMID 11266125.
Lai CH, Chiu JY, Lin W (2001). "Identification of the human crooked neck gene by comparative gene identification.". Biochim. Biophys. Acta 1517 (3): 449–54. PMID 11342225.
Fuchs M, Gerber J, Drapkin R, et al. (2001). "The p400 complex is an essential E1A transformation target.". Cell 106 (3): 297–307. PMID 11509179.
Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
Park J, Wood MA, Cole MD (2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.". Mol. Cell. Biol. 22 (5): 1307–16. PMID 11839798.
Ohfuchi E, Nishimori K, Harata M (2003). "Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm.". Biosci. Biotechnol. Biochem. 66 (8): 1740–3. PMID 12353638.
Kuroda Y, Oma Y, Nishimori K, et al. (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.". Biochem. Biophys. Res. Commun. 299 (2): 328–34. PMID 12437990.