ACTA2

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Actin, alpha 2, smooth muscle, aorta
PDB rendering based on 1atn.
Available structures: 1atn, 1c0f, 1c0g, 1d4x, 1dej, 1eqy, 1esv, 1h1v, 1hlu, 1ijj, 1j6z, 1kxp, 1lcu, 1lot, 1m8q, 1ma9, 1mdu, 1mvw, 1nlv, 1nm1, 1nmd, 1nwk, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g, 1p8z, 1qz5, 1qz6, 1rdw, 1rfq, 1rgi, 1s22, 1sqk, 1t44, 1wua, 1y64, 1yxq, 2a3z, 2a40, 2a41, 2a42, 2a5x, 2asm, 2aso, 2asp, 2btf, 2d1k, 2ff3, 2ff6, 2fxu, 2gwj, 2gwk, 2hf3, 2hf4, 2hmp, 2oan, 2q1n, 2q31, 2q36
Identifiers
Symbol(s) ACTA2; ACTSA
External IDs OMIM: 102620 MGI: 87909 HomoloGene: 48026
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 59 11475
Ensembl ENSG00000107796 ENSMUSG00000035783
Uniprot P62736 Q3U122
Refseq NM_001613 (mRNA)
NP_001604 (protein)		 NM_007392 (mRNA)
NP_031418 (protein)
Location Chr 10: 90.68 - 90.74 Mb Chr 19: 34.31 - 34.32 Mb
Pubmed search [1] [2]

Actin, alpha 2, smooth muscle, aorta, also known as ACTA2, is a human gene.[1]

Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[1]

[edit] References

  1. ^ a b Entrez Gene: ACTA2 actin, alpha 2, smooth muscle, aorta.

[edit] Further reading

  • Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639. 
  • Adams LD, Tomasselli AG, Robbins P, et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.". AIDS Res. Hum. Retroviruses 8 (2): 291–5. PMID 1540415. 
  • Harris DE, Warshaw DM, Periasamy M (1992). "Nucleotide sequences of the rabbit alpha-smooth-muscle and beta-non-muscle actin mRNAs.". Gene 112 (2): 265–6. PMID 1555776. 
  • Tomasselli AG, Hui JO, Adams L, et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279. 
  • Jahoda CA, Reynolds AJ, Chaponnier C, et al. (1991). "Smooth muscle alpha-actin is a marker for hair follicle dermis in vivo and in vitro.". J. Cell. Sci. 99 ( Pt 3): 627–36. PMID 1939373. 
  • Ueyama H, Ohsugi R (1990). "TaqI polymorphism in the 3' flanking region of the human aortic smooth muscle actin gene.". Nucleic Acids Res. 18 (5): 1318. PMID 1969628. 
  • Shoeman RL, Kesselmier C, Mothes E, et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease.". FEBS Lett. 278 (2): 199–203. PMID 1991513. 
  • Nakano Y, Nishihara T, Sasayama S, et al. (1991). "Transcriptional regulatory elements in the 5' upstream and first intron regions of the human smooth muscle (aortic type) alpha-actin-encoding gene.". Gene 99 (2): 285–9. PMID 2022339. 
  • Reddy S, Ozgur K, Lu M, et al. (1990). "Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region.". J. Biol. Chem. 265 (3): 1683–7. PMID 2295650. 
  • Ueyama H, Bruns G, Kanda N (1990). "Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10.". Jinrui Idengaku Zasshi 35 (2): 145–50. PMID 2398629. 
  • Kamada S, Nakano Y, Kakunaga T (1990). "Structure of 3'-downstream segment of the human smooth muscle (aortic-type) alpha-actin-encoding gene and isolation of the specific DNA probe.". Gene 84 (2): 455–62. PMID 2612915. 
  • Kamada S, Kakunaga T (1989). "The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA.". Nucleic Acids Res. 17 (4): 1767. PMID 2701935. 
  • Kedes L, Ng SY, Lin CS, et al. (1986). "The human beta-actin multigene family.". Trans. Assoc. Am. Physicians 98: 42–6. PMID 3842206. 
  • Ueyama H, Hamada H, Battula N, Kakunaga T (1984). "Structure of a human smooth muscle actin gene (aortic type) with a unique intron site.". Mol. Cell. Biol. 4 (6): 1073–8. PMID 6330528. 
  • Strauch AR, Rubenstein PA (1984). "A vascular smooth muscle alpha-isoactin biosynthetic intermediate in BC3H1 cells. Identification of acetylcysteine at the NH2 terminus.". J. Biol. Chem. 259 (11): 7224–9. PMID 6725286. 
  • Ueyama H, Inazawa J, Ariyama T, et al. (1995). "Reexamination of chromosomal loci of human muscle actin genes by fluorescence in situ hybridization.". Jpn. J. Hum. Genet. 40 (1): 145–8. PMID 7780165. 
  • Arora PD, McCulloch CA (1994). "Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts.". J. Cell. Physiol. 159 (1): 161–75. doi:10.1002/jcp.1041590120. PMID 8138584. 
  • Iwata Y, Pan Y, Yoshida T, et al. (1998). "Alpha1-syntrophin has distinct binding sites for actin and calmodulin.". FEBS Lett. 423 (2): 173–7. PMID 9512352. 
  • Comer KA, Dennis PA, Armstrong L, et al. (1998). "Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein.". Oncogene 16 (10): 1299–308. doi:10.1038/sj.onc.1201645. PMID 9546431. 
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