ACSL1

From Wikipedia, the free encyclopedia

Acyl-CoA synthetase long-chain family member 1

Identifiers

ACSL1; ACS1; FACL1; FACL2; LACS; LACS1; LACS2

External IDs

OMIM: 152425 MGI: 102797 HomoloGene: 37561

Gene ontology
Molecular Function:	• magnesium ion binding • catalytic activity • long-chain-fatty-acid-CoA ligase activity • ligase activity
Cellular Component:	• mitochondrion • peroxisome • membrane • integral to membrane
Biological Process:	• lipid metabolic process • fatty acid metabolic process • digestion • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001995 (mRNA)
NP_001986 (protein)

XM_991183 (mRNA)
XP_996277 (protein)

Location

Chr 4: 185.91 - 185.98 Mb

Chr 8: 47.97 - 48.03 Mb

Pubmed search

[1]

[2]

Acyl-CoA synthetase long-chain family member 1, also known as ACSL1, is a human gene.^[1]

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACSL1 acyl-CoA synthetase long-chain family member 1.

[edit] Further reading

Stanczak H, Stanczak JJ, Singh I (1992). "Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1).". Cytogenet. Cell Genet. 59 (1): 17–9. PMID 1531127.
Amigo L, McElroy MC, Morales MN, Bronfman M (1992). "Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase.". Biochem. J. 284 ( Pt 1): 283–7. PMID 1599407.
Abe T, Fujino T, Fukuyama R, et al. (1992). "Human long-chain acyl-CoA synthetase: structure and chromosomal location.". J. Biochem. 111 (1): 123–8. PMID 1607358.
Lageweg W, Wanders RJ, Tager JM (1991). "Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study.". Eur. J. Biochem. 196 (2): 519–23. PMID 2007410.
Suzuki H, Kawarabayasi Y, Kondo J, et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase.". J. Biol. Chem. 265 (15): 8681–5. PMID 2341402.
Singh I, Bhushan A, Relan NK, Hashimoto T (1989). "Acyl-CoA ligases from rat brain microsomes: an immunochemical study.". Biochim. Biophys. Acta 963 (3): 509–14. PMID 2973813.
Bierbach H (1981). "Studies on long chain fatty acid:CoA ligase from human small intestine.". Gut 21 (8): 689–94. PMID 7429333.
Cantú ES, Sprinkle TJ, Ghosh B, Singh I (1996). "The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels.". Genomics 28 (3): 600–2. doi:10.1006/geno.1995.1199. PMID 7490105.
Wu P, Bremer J (1994). "Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase.". Biochim. Biophys. Acta 1215 (1-2): 87–92. PMID 7948012.
Singh I, Lazo O, Kremser K (1993). "Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain.". Biochim. Biophys. Acta 1170 (1): 44–52. PMID 8399326.
Ghosh B, Barbosa E, Singh I (1996). "Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.". Mol. Cell. Biochem. 151 (1): 77–81. PMID 8584017.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (2000). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.". Biochem. J. 344 Pt 1: 135–43. PMID 10548543.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mashek DG, Bornfeldt KE, Coleman RA, et al. (2005). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.". J. Lipid Res. 45 (10): 1958–61. doi:10.1194/jlr.E400002-JLR200. PMID 15292367.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.". BMC Mol. Biol. 7: 21. doi:10.1186/1471-2199-7-21. PMID 16834775.