ACSBG1

From Wikipedia, the free encyclopedia

Acyl-CoA synthetase bubblegum family member 1

Identifiers

ACSBG1; BG1; BGM; FLJ30320; GR-LACS; KIAA0631; MGC14352; hBG1; hsBG

External IDs

Gene ontology
Molecular Function:	• catalytic activity • long-chain-fatty-acid-CoA ligase activity • very-long-chain-fatty-acid-CoA ligase activity
Cellular Component:	• cytoplasm
Biological Process:	• very-long-chain fatty acid metabolic process • long-chain fatty acid metabolic process • metabolic process • myelination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015162 (mRNA)
NP_055977 (protein)

NM_053178 (mRNA)
NP_444408 (protein)

Location

Chr 15: 76.25 - 76.31 Mb

Chr 9: 54.4 - 54.46 Mb

Pubmed search

[1]

[2]

Acyl-CoA synthetase bubblegum family member 1, also known as ACSBG1, is a human gene.^[1]

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Steinberg SJ, Morgenthaler J, Heinzer AK, et al. (2001). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids.". J. Biol. Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.
Moriya-Sato A, Hida A, Inagawa-Ogashiwa M, et al. (2001). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues.". Biochem. Biophys. Res. Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pei Z, Oey NA, Zuidervaart MM, et al. (2004). "The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation..". J. Biol. Chem. 278 (47): 47070–8. doi:10.1074/jbc.M310075200. PMID 12975357.
Fraisl P, Forss-Petter S, Zigman M, Berger J (2004). "Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.". Biochem. J. 377 (Pt 1): 85–93. doi:10.1042/BJ20031062. PMID 14516277.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Asheuer M, Bieche I, Laurendeau I, et al. (2005). "Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy.". Hum. Mol. Genet. 14 (10): 1293–303. doi:10.1093/hmg/ddi140. PMID 15800013.