Aconitate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, an aconitate decarboxylase (EC 4.1.1.6) is an enzyme that catalyzes the chemical reaction

cis-aconitate itaconate + CO₂

Hence, this enzyme has one substrate, cis-aconitate, and two products, itaconate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is cis-aconitate carboxy-lyase (itaconate-forming). Other names in common use include cis-aconitic decarboxylase, CAD, cis-aconitate carboxy-lyase, and cis-aconitate carboxy-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

[edit] References

• IUBMB entry for 4.1.1.6
• BRENDA references for 4.1.1.6 (Recommended.)
• PubMed references for 4.1.1.6
• PubMed Central references for 4.1.1.6
• Google Scholar references for 4.1.1.6
• BENTLEY R, THIESSEN CP (1957). "Biosynthesis of itaconic acid in Aspergillus terreus. III. The properties and reaction mechanism of cis-aconitic acid decarboxylase". J. Biol. Chem. 226: 703–20. PMID 13438855. 

[edit] External links

The CAS registry number for this enzyme class is 9025-01-8.

• IUBMB entry for 4.1.1.6

• KEGG entry for 4.1.1.6

• BRENDA entry for 4.1.1.6

• NiceZyme view of 4.1.1.6

• EC2PDB: PDB structures for 4.1.1.6

• PRIAM entry for 4.1.1.6

• PUMA2 entry for 4.1.1.6

• IntEnz: Integrated Enzyme entry for 4.1.1.6

• MetaCyc entry for 4.1.1.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047613: aconitate decarboxylase

• AMIGO entry for GO code 0047613: aconitate decarboxylase