ACOT11

From Wikipedia, the free encyclopedia

Acyl-CoA thioesterase 11

Identifiers

ACOT11; BFIT; BFIT1; BFIT2; KIAA0707; STARD14; THEA; THEM1

External IDs

OMIM: 606803 MGI: 1913736 HomoloGene: 11977

Gene ontology
Molecular Function:	• carboxylesterase activity • acyl-CoA thioesterase activity • hydrolase activity
Cellular Component:	• cytoplasm
Biological Process:	• fatty acid metabolic process • intracellular signaling cascade • response to temperature stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015547 (mRNA)
NP_056362 (protein)

NM_025590 (mRNA)
NP_079866 (protein)

Location

Chr 1: 54.79 - 54.88 Mb

Chr 4: 106.24 - 106.3 Mb

Pubmed search

[1]

[2]

Acyl-CoA thioesterase 11, also known as ACOT11, is a human gene.^[1]

This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACOT11 acyl-CoA thioesterase 11.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Adams SH, Chui C, Schilbach SL, et al. (2001). "BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity.". Biochem. J. 360 (Pt 1): 135–42. PMID 11696000.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hunt MC, Yamada J, Maltais LJ, et al. (2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.". J. Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
Hunt MC, Rautanen A, Westin MA, et al. (2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157.