Acid-CoA ligase (GDP-forming)

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In enzymology, an acid-CoA ligase (GDP-forming) (EC 6.2.1.10) is an enzyme that catalyzes the chemical reaction

GTP + an acid + CoA GDP + phosphate + acyl-CoA

The 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acid:CoA ligase (GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming).

[edit] References

• IUBMB entry for 6.2.1.10
• BRENDA references for 6.2.1.10 (Recommended.)
• PubMed references for 6.2.1.10
• PubMed Central references for 6.2.1.10
• Google Scholar references for 6.2.1.10
• Rossi CR and Gibson DM (1964). "Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria". J. Biol. Chem. 239: 1694–1699. 

[edit] External links

The CAS registry number for this enzyme class is 37318-59-5.

• IUBMB entry for 6.2.1.10

• KEGG entry for 6.2.1.10

• BRENDA entry for 6.2.1.10

• NiceZyme view of 6.2.1.10

• EC2PDB: PDB structures for 6.2.1.10

• PRIAM entry for 6.2.1.10

• PUMA2 entry for 6.2.1.10

• IntEnz: Integrated Enzyme entry for 6.2.1.10

• MetaCyc entry for 6.2.1.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047612: acid-CoA ligase (GDP-forming)

• AMIGO entry for GO code 0047612: acid-CoA ligase (GDP-forming)