ACIN1

From Wikipedia, the free encyclopedia

Apoptotic chromatin condensation inducer 1

Identifiers

ACIN1; ACN; ACINUS; DKFZp667N107; KIAA0670

External IDs

OMIM: 604562 MGI: 1891824 HomoloGene: 22853

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • ATPase activity • enzyme binding
Cellular Component:	• nucleus • nucleolus
Biological Process:	• apoptosis • erythrocyte differentiation • apoptotic chromosome condensation • positive regulation of monocyte differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014977 (mRNA)
NP_055792 (protein)

NM_019567 (mRNA)
NP_062513 (protein)

Location

Chr 14: 22.6 - 22.63 Mb

Chr 14: 53.6 - 53.64 Mb

Pubmed search

[1]

[2]

Apoptotic chromatin condensation inducer 1, also known as ACIN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1.

[edit] Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811.
Sahara S, Aoto M, Eguchi Y, et al. (1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.". Nature 401 (6749): 168-73. doi:10.1038/43678. PMID 10490026.
Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation.". J. Exp. Med. 193 (2): 247-54. PMID 11208865.
Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages.". Blood 100 (13): 4446-53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics 3 (3): 279-86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339-46. doi:10.1021/pr050048h. PMID 16083285.
Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.". EMBO J. 24 (20): 3543-54. doi:10.1038/sj.emboj.7600823. PMID 16177823.
Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis.". J. Biol. Chem. 281 (18): 12475-84. doi:10.1074/jbc.M509859200. PMID 16537548.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma.". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1 (2): 160-7. PMID 17409846.