Talk:Acetazolamide
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Note that the medical disclaimer was originally added before the "Disclaimers" link appeared as part of the standard page header. RedWolf 03:59, Feb 24, 2004 (UTC)
Could somebody please add information about Acetazolamide's use in the treatment of Hypokalemic periodic paralysis? My wife suffered from HPP for over 30 years and when she began treatment using Acetazolamide her episodes have decreased from three to four per week to maybe once per year. HPP and it's associated conditions are exceedingly rare at about one per hundred thousand people.
[edit] Acetazolamide for migraine-associated vertigo
Would like someone to add research on how otolaryngologists (ENTs) are using Diamox to treat migraine-associated vertigo. These attacks or episodes are severe and debilitating. I'm being treated via Diamox. Would like a medical specialist to add his/her findings to this page. SedonaSue 00:57, 21 July 2007 (UTC)
- Quick search at PubMed shows up, some interesting stuff. But not yet fully proven, nor commonly accepted into routine clinical practice and probably comes under research off-license usage (although I'm glad you found it helpful):
- Ambrosini A, Pierelli F, Schoenen J (2003). "Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs". Cephalalgia : an international journal of headache 23 (2): 75-8. PMID 12603362.
- De Simone R, Marano E, Di Stasio E, Bonuso S, Fiorillo C, Bonavita V (2005). "Acetazolamide efficacy and tolerability in migraine with aura: a pilot study". Headache 45 (4): 385-6. doi:. PMID 15836579.
- As a secondary source review:
- Black DF (2006). "Sporadic and familial hemiplegic migraine: diagnosis and treatment". Seminars in neurology 26 (2): 208-16. doi:. PMID 16628531. - which concludes "Thus far, treatment trials are anecdotal, although verapamil and acetazolamide have shown promise"
- Somewhat different findings are:
- Sakashita Y, Kanai M, Sugimoto T, Taki S, Takamori M (1997). "Changes in cerebral blood flow and vasoreactivity in response to acetazolamide in patients with transient global amnesia". J. Neurol. Neurosurg. Psychiatr. 63 (5): 605-10. PMID 9408101.
- Warner JS, Wamil AW, McLean MJ (1994). "Acetazolamide for the treatment of chronic paroxysmal hemicrania". Headache 34 (10): 597-9. PMID 7843957.
- David Ruben Talk 02:50, 21 July 2007 (UTC)
David Ruben, thank you for the links. I wish to remain anonymous for now, however, 3 months after my first post, the Diamox seems to be working for me. In either 2002 or 2003, I began having about 3 episodes a year of debilitating vertigo. I rarely have headaches and "never" had migraines. When the otolaryngologist told me I had "silent", or common, migraines causing the vertigo, I was honestly shocked. Then, I remembered that a year ago I experienced one aura with a migraine headache. The vertigo began in my mid-40s, so I suspect my "silent" migraines and resulting vertigo may be caused by my (now) fluctuating hormones. Plus, now I am more sensitive to barometric changes.
A woman I know in her 30s was also on Diamox for vertigo, and she has experienced success as well. She's encouraged me to stay on my doctor's program of taking Diamox for six months. Then, he will wean me off of it. She no longer needs to be on acetazolamide. She saw four different physicians, who said "it was all in her head". Doctor #5 told her, "well, they were right in a way...it is in your head...migraines."
I want to learn more about the effects of calcium and potassium levels, plus an acidic pH environment versus a base/alkaline.
If the Diamox therapy works for me like it did for my colleague, I'll be thrilled and the side effects will be worth it. I now drink a glass of lemonade daily to prevent kidney stones (recommended by my husband's urologist), and I now eat one banana each morning for potassium. However, I now bruise very easily, and the bruises take twice as long to heal. I've gotten used to the tingling and it happens only sporadically, and usually right after I have taken one of the 2x per diem 125 mg doses. My doctor wanted to gradually increase the dosages to 500mg/per diem, but agreed to keep me at 250mg as long as it worked. It's better than waking up one morning with the entire universe spinning rapidly around you, and all you can do is close your eyes and stay in bed, not daring to move your head, so you can try to "sleep" away the first 24 hours. (Meclizine can only do so much.) Then, deal with one or more weeks of constant, low-grade dizziness.
That's why I hope others post more links or comments related to acetazolamide studies and migraine-associated vertigo. I apologize this is so long, but together maybe we all could help other people get their lives back.SedonaSue 06:35, 23 September 2007 (UTC)
