Acetylglutamate kinase

From Wikipedia, the free encyclopedia

In enzymology, an acetylglutamate kinase (EC 2.7.2.8) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-L-glutamate ADP + N-acetyl-L-glutamyl 5-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-L-glutamate, whereas its two products are ADP and N-acetyl-L-glutamyl 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-L-glutamate 5-phosphotransferase. Other names in common use include N-acetylglutamate 5-phosphotransferase, acetylglutamate phosphokinase, N-acetylglutamate phosphokinase, N-acetylglutamate kinase, and N-acetylglutamic 5-phosphotransferase. This enzyme participates in urea cycle and metabolism of amino groups.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1GS5, 1GSJ, 1OH9, 1OHA, 1OHB, 2AP9, 2BTY, 2BUF, and 2RD5.

[edit] References

• IUBMB entry for 2.7.2.8
• BRENDA references for 2.7.2.8 (Recommended.)
• PubMed references for 2.7.2.8
• PubMed Central references for 2.7.2.8
• Google Scholar references for 2.7.2.8
• BAICH A, VOGEL HJ (1962). "N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli". Biochem. Biophys. Res. Commun. 7: 491–6. PMID 13863980. 
• Farago A, Denes G (1967). "Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. II Purification and properties of N-acetylglutamate 5-phosphotransferase, the allosteric enzyme of the pathway". Biochim. Biophys. Acta. 136: 6–18. PMID 6040410. 
• Vogel HJ and McLellan WL (1970). "N-Acetyl-gamma-glutamokinase (Escherichia coli)". Methods Enzymol. 17A: 251–255. 

[edit] External links

The CAS registry number for this enzyme class is 9027-58-1.

• IUBMB entry for 2.7.2.8

• KEGG entry for 2.7.2.8

• BRENDA entry for 2.7.2.8

• NiceZyme view of 2.7.2.8

• EC2PDB: PDB structures for 2.7.2.8

• PRIAM entry for 2.7.2.8

• PUMA2 entry for 2.7.2.8

• IntEnz: Integrated Enzyme entry for 2.7.2.8

• MetaCyc entry for 2.7.2.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003991: acetylglutamate kinase

• AMIGO entry for GO code 0003991: acetylglutamate kinase