Acetylacetone-cleaving enzyme

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In enzymology, an acetylacetone-cleaving enzyme (EC 1.13.11.50) is an enzyme that catalyzes the chemical reaction

pentane-2,4-dione + O₂ acetate + 2-oxopropanal

Thus, the two substrates of this enzyme are pentane-2,4-dione and O₂, whereas its two products are acetate and 2-oxopropanal.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is acetylacetone:oxygen oxidoreductase. Other names in common use include Dke1, acetylacetone dioxygenase, diketone cleaving dioxygenase, and diketone cleaving enzyme.

[edit] References

• IUBMB entry for 1.13.11.50
• BRENDA references for 1.13.11.50 (Recommended.)
• PubMed references for 1.13.11.50
• PubMed Central references for 1.13.11.50
• Google Scholar references for 1.13.11.50
• Straganz GD, Glieder A, Brecker L, Ribbons DW, Steiner W (2003). "Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii". Biochem. J. 369: 573–81. doi:10.1042/BJ20021047. PMID 12379146. 

[edit] External links

The CAS registry number for this enzyme class is 524047-53-8.

• IUBMB entry for 1.13.11.50

• KEGG entry for 1.13.11.50

• BRENDA entry for 1.13.11.50

• NiceZyme view of 1.13.11.50

• EC2PDB: PDB structures for 1.13.11.50

• PRIAM entry for 1.13.11.50

• PUMA2 entry for 1.13.11.50

• IntEnz: Integrated Enzyme entry for 1.13.11.50

• MetaCyc entry for 1.13.11.50

• Atomic-resolution structures of enzymes belonging to this class