Acetyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an acetyl-CoA hydrolase (EC 3.1.2.1) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O CoA + acetate

Thus, the two substrates of this enzyme are acetyl-CoA and H₂O, whereas its two products are CoA and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acetyl-CoA hydrolase. Other names in common use include acetyl-CoA deacylase, acetyl-CoA acylase, acetyl coenzyme A hydrolase, acetyl coenzyme A deacylase, acetyl coenzyme A acylase, and acetyl-CoA thiol esterase. This enzyme participates in pyruvate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H4U.

[edit] References

• IUBMB entry for 3.1.2.1
• BRENDA references for 3.1.2.1 (Recommended.)
• PubMed references for 3.1.2.1
• PubMed Central references for 3.1.2.1
• Google Scholar references for 3.1.2.1
• Gergely J, Hele P and Ramakrishnan CV (1952). "Succinyl and acetyl coenzyme A deacylases". J. Biol. Chem. 198: 323–334. 

[edit] External links

The CAS registry number for this enzyme class is 9027-54-7.

• IUBMB entry for 3.1.2.1

• KEGG entry for 3.1.2.1

• BRENDA entry for 3.1.2.1

• NiceZyme view of 3.1.2.1

• EC2PDB: PDB structures for 3.1.2.1

• PRIAM entry for 3.1.2.1

• PUMA2 entry for 3.1.2.1

• IntEnz: Integrated Enzyme entry for 3.1.2.1

• MetaCyc entry for 3.1.2.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003986: acetyl-CoA hydrolase

• AMIGO entry for GO code 0003986: acetyl-CoA hydrolase