Acetoin-ribose-5-phosphate transaldolase

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In enzymology, an acetoin-ribose-5-phosphate transaldolase (EC 2.2.1.4) is an enzyme that catalyzes the chemical reaction

3-hydroxybutan-2-one + D-ribose 5-phosphate $\rightleftharpoons$ acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate

Thus, the two substrates of this enzyme are 3-hydroxybutan-2-one and D-ribose 5-phosphate, whereas its two products are acetaldehyde and 1-deoxy-D-altro-heptulose 7-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). The systematic name of this enzyme class is 3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase. Other names in common use include 1-deoxy-D-altro-heptulose-7-phosphate synthetase, 1-deoxy-D-altro-heptulose-7-phosphate synthase, 3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase [wrong, and substrate name]. It employs one cofactor, thiamin diphosphate.

[edit] References

IUBMB entry for 2.2.1.4
BRENDA references for 2.2.1.4 (Recommended.)
PubMed references for 2.2.1.4
PubMed Central references for 2.2.1.4
Google Scholar references for 2.2.1.4
Yokota A and Sasajima K (1983). "Enzymatic formation of a new monosaccharide, 1-deoxy-D-altro-heptulose phosphate, from DL-acetoin and D-ribose 5-phosphate by a transketolase mutant of Bacillus pumilus". Agric. Biol. Chem. 47: 1545–1553.