Acetoacetyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an acetoacetyl-CoA hydrolase (EC 3.1.2.11) is an enzyme that catalyzes the chemical reaction

acetoacetyl-CoA + H₂O CoA + acetoacetate

Thus, the two substrates of this enzyme are acetoacetyl-CoA and H₂O, whereas its two products are CoA and acetoacetate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase. This enzyme participates in butanoate metabolism.

[edit] References

• IUBMB entry for 3.1.2.11
• BRENDA references for 3.1.2.11 (Recommended.)
• PubMed references for 3.1.2.11
• PubMed Central references for 3.1.2.11
• Google Scholar references for 3.1.2.11
• Aragon JJ, Lowenstein JM (1983). "A survey of enzymes which generate or use acetoacetyl thioesters in rat liver". J. Biol. Chem. 258: 4725–33. PMID 6131897. 
• DRUMMOND GI, STERN JR (1960). "Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver". J. Biol. Chem. 235: 318–25. PMID 13818236. 

[edit] External links

The CAS registry number for this enzyme class is 37288-10-1.

• IUBMB entry for 3.1.2.11

• KEGG entry for 3.1.2.11

• BRENDA entry for 3.1.2.11

• NiceZyme view of 3.1.2.11

• EC2PDB: PDB structures for 3.1.2.11

• PRIAM entry for 3.1.2.11

• PUMA2 entry for 3.1.2.11

• IntEnz: Integrated Enzyme entry for 3.1.2.11

• MetaCyc entry for 3.1.2.11

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047603: acetoacetyl-CoA hydrolase

• AMIGO entry for GO code 0047603: acetoacetyl-CoA hydrolase