Acetoacetate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, an acetoacetate-CoA ligase (EC 6.2.1.16) is an enzyme that catalyzes the chemical reaction

ATP + acetoacetate + CoA AMP + diphosphate + acetoacetyl-CoA

The 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.

[edit] References

• IUBMB entry for 6.2.1.16
• BRENDA references for 6.2.1.16 (Recommended.)
• PubMed references for 6.2.1.16
• PubMed Central references for 6.2.1.16
• Google Scholar references for 6.2.1.16
• Fukui T, Ito M, Tomita K (1982). "Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M". Eur. J. Biochem. 127: 423–8. PMID 7140777. 

[edit] External links

The CAS registry number for this enzyme class is 39394-62-2.

• IUBMB entry for 6.2.1.16

• KEGG entry for 6.2.1.16

• BRENDA entry for 6.2.1.16

• NiceZyme view of 6.2.1.16

• EC2PDB: PDB structures for 6.2.1.16

• PRIAM entry for 6.2.1.16

• PUMA2 entry for 6.2.1.16

• IntEnz: Integrated Enzyme entry for 6.2.1.16

• MetaCyc entry for 6.2.1.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030729: acetoacetate-CoA ligase

• AMIGO entry for GO code 0030729: acetoacetate-CoA ligase