Acetate CoA-transferase

From Wikipedia, the free encyclopedia

In enzymology, an acetate CoA-transferase (EC 2.8.3.8) is an enzyme that catalyzes the chemical reaction

acyl-CoA + acetate $\rightleftharpoons$ a fatty acid anion + acetyl-CoA

Thus, the two substrates of this enzyme are acyl-CoA and acetate, whereas its two products are fatty acid anion and acetyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acyl-CoA:acetate CoA-transferase. Other names in common use include acetate coenzyme A-transferase, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, and succinyl-CoA:acetate CoA transferase. This enzyme participates in 4 metabolic pathways: benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1K6D.

[edit] References

IUBMB entry for 2.8.3.8
BRENDA references for 2.8.3.8 (Recommended.)
PubMed references for 2.8.3.8
PubMed Central references for 2.8.3.8
Google Scholar references for 2.8.3.8
Vanderwinkel E, Furmanski P, Reeves HC, Ajl SJ (1968). "Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity". Biochem. Biophys. Res. Commun. 33: 902–8. doi:10.1016/0006-291X(68)90397-5. PMID 4884054.
Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184: 207–15. doi:10.1128/JB.184.1.207-215.2002. PMID 11741862.
Gobel M, Kassel-Cati K, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184: 216–23. doi:10.1128/JB.184.1.216-223.2002. PMID 11741863.