Acetate-CoA ligase (ADP-forming)

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In enzymology, an acetate-CoA ligase (ADP-forming) (EC 6.2.1.13) is an enzyme that catalyzes the chemical reaction

ATP + acetate + CoA ADP + phosphate + acetyl-CoA

The 3 substrates of this enzyme are ATP, acetate, and CoA, whereas its 3 products are ADP, phosphate, and acetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetate:CoA ligase (ADP-forming). Other names in common use include acetyl-CoA synthetase (ADP-forming), acetyl coenzyme A synthetase (adenosine diphosphate-forming), and acetate thiokinase. This enzyme participates in pyruvate metabolism and propanoate metabolism.

[edit] References

• IUBMB entry for 6.2.1.13
• BRENDA references for 6.2.1.13 (Recommended.)
• PubMed references for 6.2.1.13
• PubMed Central references for 6.2.1.13
• Google Scholar references for 6.2.1.13
• Reeves RE, Warren LG, Susskind B, Lo HS (1977). "An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase". J. Biol. Chem. 252: 726–31. PMID 13076. 

[edit] External links

The CAS registry number for this enzyme class is 62009-85-2.

• IUBMB entry for 6.2.1.13

• KEGG entry for 6.2.1.13

• BRENDA entry for 6.2.1.13

• NiceZyme view of 6.2.1.13

• EC2PDB: PDB structures for 6.2.1.13

• PRIAM entry for 6.2.1.13

• PUMA2 entry for 6.2.1.13

• IntEnz: Integrated Enzyme entry for 6.2.1.13

• MetaCyc entry for 6.2.1.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043758: acetate-CoA ligase (ADP-forming)

• AMIGO entry for GO code 0043758: acetate-CoA ligase (ADP-forming)