Talk:ABVD

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Alright, I have expanded this page and removed the stub. Comments? MastCell 17:52, 11 August 2006 (UTC)

Looks great! --WS 19:07, 11 August 2006 (UTC)

How would you feel about moving the "History" section back up near the top, underneath "Indications"? It seems a little anticlimactic at the end. MastCell 21:06, 11 August 2006 (UTC)

So I moved the "History" section toward the top... I lean toward this organization. Comments? MastCell 03:01, 13 August 2006 (UTC)

Reference 12 seems to infer that the secondary cancer risk is much lower with ABVD than MOPP. Although it remains elevated, I would suggest that the statement made regarding secondary malignancies is misleading and should maybe be placed into context. The paper emphasises that leukaemia is the most devastating secondary (presumably in reference to treatability rather than incidence), but this has lowered with ABVD (over MOPP). The study observed 26 cases of gastrointestinal tumours, 13 cases of lung cancer and 27 instances of breast cancer out of over 100 solid tumours manifesting themselves. —The preceding unsigned comment was added by 152.78.98.1 (talk • contribs).

Yes... looking again at that study, it seems that most of the patients they followed were treated with MOPP, or MOPP/ABVD hybrid regimens. Not many were treated with ABVD, so the relevance is questionable. Unfortunately, the authors didn't break down the analysis by chemo regimen. I added a little to try and clarify that the 28% finding including many patients treated with MOPP, which is known to have a higher rate of secondary malignancy. MastCell 22:16, 7 December 2006 (UTC)

Hi there...as a former ABVD patient (5 years!!!) I thought it would be worth noting the concept of the "rapid responder"...after 2 cycles of ABVD it was decided due to PET scan that I would receive 4 cycles rather than 6 due to the complete absence of activity on the PET. Not sure how wide-spread this practice is, but it seems to me to be a significant advance (?) in the practice of the therapy. —The preceding unsigned comment was added by 71.96.253.226 (talk)

Yes, PET scan has definitely had an impact in how Hodgkin's is treated. I think this might be better described in the article on Hodgkin disease so as to avoid duplication. Feel free to have a look - that article could definitely stand improvement. Congratulations on being 5 years out! MastCell ^Talk 23:41, 4 June 2007 (UTC)

[edit] Another long term side effect

Osteoprosis is one of the long term side effects that I am dealing with. I have been off ABVD for 3 years now and was diagnosised with severe osteoporosis this past year. No I am not your normal osteoporosis diagnosee. I am a 36 year old male in the U.S. Army. My osteoporosis is bad enough that I am being medically retired.--Dennis scales 19:44, 12 July 2007 (UTC)

I'll look into that. If you don't mind my asking, were you on steroids (e.g. prednisone) for any prolonged periods (more than a week or two) during or after your treatment? Steroids certainly enhance bone loss, though I don't know about ABVD itself... MastCell ^Talk 20:34, 12 July 2007 (UTC)

The only other thing that I was on during the entire treatment process was neupogen for neutropenia. --Dennis scales 21:30, 16 July 2007 (UTC)