ABTB1

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Ankyrin repeat and BTB (POZ) domain containing 1
Identifiers
Symbol(s) ABTB1; BPOZ; EF1ABP; MGC20585; PP2259
External IDs OMIM: 608308 MGI: 1933148 HomoloGene: 32731
Orthologs
Human Mouse
Entrez 80325 80283
Ensembl ENSG00000114626 ENSMUSG00000030083
Uniprot Q969K4 Q99LJ2
Refseq NM_032548 (mRNA)
NP_115937 (protein)		 NM_030251 (mRNA)
NP_084527 (protein)
Location Chr 3: 128.87 - 128.88 Mb Chr 6: 88.8 - 88.81 Mb
Pubmed search [1] [2]

Ankyrin repeat and BTB (POZ) domain containing 1, also known as ABTB1, is a human gene.[1]

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1.

[edit] Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724-9. doi:10.1073/pnas.0404089101. PMID 15498874. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Unoki M, Nakamura Y (2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.". Oncogene 20 (33): 4457-65. doi:10.1038/sj.onc.1204608. PMID 11494141. 
  • Dai KS, Wei W, Liew CC (2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain.". Biochem. Biophys. Res. Commun. 273 (3): 991-6. doi:10.1006/bbrc.2000.3053. PMID 10891360. 
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