ABI3

From Wikipedia, the free encyclopedia

ABI gene family, member 3

Identifiers

ABI3; NESH; SSH3BP3

External IDs

OMIM: 606363 MGI: 1913860 HomoloGene: 9505

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytoplasm
Biological Process:	• cell motility • regulation of cell migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016428 (mRNA)
NP_057512 (protein)

NM_025659 (mRNA)
NP_079935 (protein)

Location

Chr 17: 44.64 - 44.66 Mb

Chr 11: 95.65 - 95.66 Mb

Pubmed search

[1]

[2]

ABI gene family, member 3, also known as ABI3, is a human gene.^[1]

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase.^[1]

[edit] References

^ ^a ^b Entrez Gene: ABI3 ABI gene family, member 3.

[edit] Further reading

Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).". Int. J. Mol. Med. 9 (6): 591-5. PMID 12011975.
Miyazaki K, Matsuda S, Ichigotani Y, et al. (2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.". Biochim. Biophys. Acta 1493 (1-2): 237-41. PMID 10978530.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Matsuda S, Iriyama C, Yokozaki S, et al. (2001). "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3.". J. Hum. Genet. 46 (8): 483-6. PMID 11501947.
Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.". Cancer Res. 62 (8): 2215-9. PMID 11956071.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.". FEBS Lett. 580 (27): 6464-70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.