ABI1

From Wikipedia, the free encyclopedia

Abl-interactor 1

Identifiers

ABI1; ABI-1; E3B1; NAP1BP; SSH3BP; SSH3BP1

External IDs

Gene ontology
Molecular Function:	• cytoskeletal protein binding
Cellular Component:	• soluble fraction • nucleus • endoplasmic reticulum • cytosol • cytoskeleton
Biological Process:	• transmembrane receptor protein tyrosine kinase signaling pathway • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001012750 (mRNA)
NP_001012768 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 10: 27.08 - 27.19 Mb

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Pubmed search

[1]

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Abl-interactor 1, also known as ABI1, is a human gene.

The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.^[1]

[edit] References

^ Entrez Gene: ABI1 abl-interactor 1.

[edit] Further reading

Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).". Int. J. Mol. Med. 9 (6): 591–5. PMID 12011975.
Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases.". Int. J. Biochem. Cell Biol. 34 (10): 1178–83. PMID 12127568.
Cardwell C (1977). "Student or worker? International Meeting of Student Nurses (European Group).". Nursing mirror and midwives journal 143 (19): 38. PMID 1049958.
Biesova Z, Piccoli C, Wong WT (1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth.". Oncogene 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.
Ziemnicka-Kotula D, Xu J, Gu H, et al. (1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton.". J. Biol. Chem. 273 (22): 13681–92. PMID 9593709.
Taki T, Shibuya N, Taniwaki M, et al. (1998). "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23).". Blood 92 (4): 1125–30. PMID 9694699.
Scita G, Nordstrom J, Carbone R, et al. (1999). "EPS8 and E3B1 transduce signals from Ras to Rac.". Nature 401 (6750): 290–3. doi:10.1038/45822. PMID 10499589.
Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551.
Fan PD, Goff SP (2000). "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases.". Mol. Cell. Biol. 20 (20): 7591–601. PMID 11003655.
Xu J, Ziemnicka D, Merz GS, Kotula L (2001). "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells.". J. Cell. Sci. 113 Pt 21: 3805–14. PMID 11034908.
Lanzetti L, Rybin V, Malabarba MG, et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.". Nature 408 (6810): 374–7. doi:10.1038/35042605. PMID 11099046.
Yamamoto A, Suzuki T, Sakaki Y (2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease.". Gene 271 (2): 159–69. PMID 11418237.
Cowan CA, Henkemeyer M (2001). "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.". Nature 413 (6852): 174–9. doi:10.1038/35093123. PMID 11557983.
Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.". Cancer Res. 62 (8): 2215–9. PMID 11956071.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMID 12522270.
Morerio C, Rosanda C, Rapella A, et al. (2003). "Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?". Cancer Genet. Cytogenet. 139 (1): 57–9. PMID 12547160.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.