ABCC12

From Wikipedia, the free encyclopedia

ATP-binding cassette, sub-family C (CFTR/MRP), member 12

Identifiers

ABCC12; MGC27071; MRP9

External IDs

OMIM: 607041 MGI: 2441679 HomoloGene: 57211

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • ATPase activity • ATPase activity, coupled to transmembrane movement of substances
Cellular Component:	• membrane • integral to membrane
Biological Process:	• transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_033226 (mRNA)
NP_150229 (protein)

XM_988275 (mRNA)
XP_993369 (protein)

Location

Chr 16: 46.67 - 46.74 Mb

Chr 8: 89.39 - 89.46 Mb

Pubmed search

[1]

[2]

ATP-binding cassette, sub-family C (CFTR/MRP), member 12, also known as ABCC12, is a human gene.^[1]

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12.

[edit] Further reading

Haimeur A, Conseil G, Deeley RG, Cole SP (2004). "The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation.". Curr. Drug Metab. 5 (1): 21-53. PMID 14965249.
Dean M, Rzhetsky A, Allikmets R (2001). "The human ATP-binding cassette (ABC) transporter superfamily.". Genome Res. 11 (7): 1156-66. doi:10.1101/gr.184901. PMID 11435397.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bera TK, Iavarone C, Kumar V, et al. (2002). "MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6997-7002. doi:10.1073/pnas.102187299. PMID 12011458.
Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.". Biochem. Biophys. Res. Commun. 288 (4): 933-9. doi:10.1006/bbrc.2001.5865. PMID 11688999.
Tammur J, Prades C, Arnould I, et al. (2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.". Gene 273 (1): 89-96. PMID 11483364.