A-412,997

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A-412,997
Systematic (IUPAC) name
N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
Identifiers
CAS number	?
ATC code	?
PubChem	10425450
Chemical data
Formula	C19H23N3O
Mol. mass	309.405 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D₄ subtype, with significantly improved selectivity over older D₄-preferring compounds such as PD-168,077 and CP-226,269.^[1] It is unclear what applications this drug might be used for, but in animal tests it induced penile erection and improved cognitive performance in rats.^[2] Also unlike other dopamine agonists, selective D₄ agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.^[3]

[edit] References

1. ^ Moreland RB, Patel M, Hsieh GC, Wetter JM, Marsh K, Brioni JD. A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacology, Biochemistry and Behaviour. 2005 Sep;82(1):140-7. PMID 16153699
2. ^ Browman KE, Curzon P, Pan JB, Molesky AL, Komater VA, Decker MW, Brioni JD, Moreland RB, Fox GB. A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacology, Biochemistry and Behaviour. 2005 Sep;82(1):148-55. PMID 16154186
3. ^ Osinski MA, Uchic ME, Seifert T, Shaughnessy TK, Miller LN, Nakane M, Cox BF, Brioni JD, Moreland RB. Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacology, Biochemistry and Behaviour. 2005 May;81(1):211-9. PMID 15894081

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