7,8-dihydroxykynurenate 8,8a-dioxygenase

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In enzymology, a 7,8-dihydroxykynurenate 8,8a-dioxygenase (EC 1.13.11.10) is an enzyme that catalyzes the chemical reaction

7,8-dihydroxykynurenate + O₂ 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate

Thus, the two substrates of this enzyme are 7,8-dihydroxykynurenate and O₂, whereas its product is 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing). Other names in common use include 7,8-dihydroxykynurenate oxygenase, and 7,8-dihydroxykynurenate 8,8alpha-dioxygenase. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 1.13.11.10
• BRENDA references for 1.13.11.10 (Recommended.)
• PubMed references for 1.13.11.10
• PubMed Central references for 1.13.11.10
• Google Scholar references for 1.13.11.10
• Seno S, Tokuyama T and Sakan T (1961). "Enzymatic degradation of kynurenic acid". Fed. Proc. 20: 3. 

[edit] External links

The CAS registry number for this enzyme class is 9029-58-7.

• IUBMB entry for 1.13.11.10

• KEGG entry for 1.13.11.10

• BRENDA entry for 1.13.11.10

• NiceZyme view of 1.13.11.10

• EC2PDB: PDB structures for 1.13.11.10

• PRIAM entry for 1.13.11.10

• PUMA2 entry for 1.13.11.10

• IntEnz: Integrated Enzyme entry for 1.13.11.10

• MetaCyc entry for 1.13.11.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047069: 7,8-dihydroxykynurenate 8,8a-dioxygenase

• AMIGO entry for GO code 0047069: 7,8-dihydroxykynurenate 8,8a-dioxygenase