6beta-hydroxyhyoscyamine epoxidase

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In enzymology, a 6beta-hydroxyhyoscyamine epoxidase (EC 1.14.11.14) is an enzyme that catalyzes the chemical reaction

(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 \rightleftharpoons scopolamine + succinate + CO2 + H2O

The 3 substrates of this enzyme are (6S)-6-hydroxyhyoscyamine, 2-oxoglutarate, and O2, whereas its 4 products are scopolamine, succinate, CO2, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming). This enzyme is also called hydroxyhyoscyamine dioxygenase. This enzyme participates in alkaloid biosynthesis ii. It has 2 cofactors: iron, and Ascorbate.

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The CAS registry number for this enzyme class is 121479-53-6.

[edit] Gene Ontology (GO) codes

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