6'-deoxychalcone synthase

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In enzymology, a 6'-deoxychalcone synthase (EC 2.3.1.170) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H⁺ 4 CoA + isoliquiritigenin + 3 CO₂ + NADP⁺ + H₂O

The 4 substrates of this enzyme are malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H⁺, whereas its 5 products are CoA, isoliquiritigenin, CO₂, NADP⁺, and H₂O. Deoxychalcone synthase catalyzed activity is involved in the biosynthesis of retrochalcone and certain phytoalexins in the cells of glycyrrhiza echinata (Russian licorice) and other leguminous plants.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing).

[edit] References

• IUBMB entry for 2.3.1.170
• BRENDA references for 2.3.1.170 (Recommended.)
• PubMed references for 2.3.1.170
• PubMed Central references for 2.3.1.170
• Google Scholar references for 2.3.1.170
• Ayabe S, Udagawa A, Furuya T (1988). "NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract". Arch. Biochem. Biophys. 261: 458–62. PMID 3355160. 

[edit] External links

The CAS registry number for this enzyme class is 114308-23-5.

• IUBMB entry for 2.3.1.170

• KEGG entry for 2.3.1.170

• BRENDA entry for 2.3.1.170

• NiceZyme view of 2.3.1.170

• EC2PDB: PDB structures for 2.3.1.170

• PRIAM entry for 2.3.1.170

• PUMA2 entry for 2.3.1.170

• IntEnz: Integrated Enzyme entry for 2.3.1.170

• MetaCyc entry for 2.3.1.170

• Atomic-resolution structures of enzymes belonging to this class