6-pyruvoyltetrahydropterin synthase

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In enzymology, a 6-pyruvoyltetrahydropterin synthase (EC 4.2.3.12) is an enzyme that catalyzes the chemical reaction

6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin $\rightleftharpoons$ 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

Hence, this enzyme has one substrate, 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin, and two products, 6-pyruvoyl-5,6,7,8-tetrahydropterin and triphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming). Other names in common use include 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-, and dihydroxypteridine triphosphate lyase. This enzyme participates in folate biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1Y13, 2A0S, 2DJ6, 2G64, and 2OBA.

[edit] References

IUBMB entry for 4.2.3.12
BRENDA references for 4.2.3.12 (Recommended.)
PubMed references for 4.2.3.12
PubMed Central references for 4.2.3.12
Google Scholar references for 4.2.3.12
Milstien S, Kaufman S (1989). "The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2'-oxo)reductase". J. Biol. Chem. 264: 8066–73. PMID 2656673.
Thony B, Leimbacher W, Burgisser D, Heizmann CW (1992). "Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme". Biochem. Biophys. Res. Commun. 189: 1437–43. doi:10.1016/0006-291X(92)90235-D. PMID 1282802.