6-pyruvoyltetrahydropterin 2'-reductase

From Wikipedia, the free encyclopedia

In enzymology, a 6-pyruvoyltetrahydropterin 2'-reductase (EC 1.1.1.220) is an enzyme that catalyzes the chemical reaction

6-lactoyl-5,6,7,8-tetrahydropterin + NADP⁺ 6-pyruvoyltetrahydropterin + NADPH + H⁺

Thus, the two substrates of this enzyme are 6-lactoyl-5,6,7,8-tetrahydropterin and NADP⁺, whereas its 3 products are 6-pyruvoyltetrahydropterin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase. Other names in common use include 6-pyruvoyltetrahydropterin reductase, 6PPH4(2'-oxo) reductase, 6-pyruvoyl tetrahydropterin (2'-oxo)reductase, 6-pyruvoyl-tetrahydropterin 2'-reductase, and pyruvoyl-tetrahydropterin reductase. This enzyme participates in folate biosynthesis.

[edit] References

• IUBMB entry for 1.1.1.220
• BRENDA references for 1.1.1.220 (Recommended.)
• PubMed references for 1.1.1.220
• PubMed Central references for 1.1.1.220
• Google Scholar references for 1.1.1.220
• Milstien S, Kaufman S (1985). "Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates". Biochem. Biophys. Res. Commun. 128: 1099–107. PMID 4004850. 

[edit] External links

The CAS registry number for this enzyme class is 97089-79-7.

• IUBMB entry for 1.1.1.220

• KEGG entry for 1.1.1.220

• BRENDA entry for 1.1.1.220

• NiceZyme view of 1.1.1.220

• EC2PDB: PDB structures for 1.1.1.220

• PRIAM entry for 1.1.1.220

• PUMA2 entry for 1.1.1.220

• IntEnz: Integrated Enzyme entry for 1.1.1.220

• MetaCyc entry for 1.1.1.220

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047028: 6-pyruvoyltetrahydropterin 2'-reductase

• AMIGO entry for GO code 0047028: 6-pyruvoyltetrahydropterin 2'-reductase