6-phosphofructo-2-kinase

From Wikipedia, the free encyclopedia

In enzymology, a 6-phosphofructo-2-kinase (EC 2.7.1.105) is an enzyme that catalyzes the chemical reaction

ATP + beta-D-fructose 6-phosphate ADP + beta-D-fructose 2,6-bisphosphate

Thus, the two substrates of this enzyme are ATP and beta-D-fructose 6-phosphate, whereas its two products are ADP and beta-D-fructose 2,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:beta-D-fructose-6-phosphate 2-phosphotransferase. Other names in common use include phosphofructokinase 2, 6-phosphofructose 2-kinase, 6-phosphofructo-2-kinase (phosphorylating), fructose 6-phosphate 2-kinase, and ATP:D-fructose-6-phosphate 2-phosphotransferase. This enzyme participates in fructose and mannose metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1BIF, 1K6M, 2AXN, 2BIF, 2DWO, 2DWP, 2I1V, and 3BIF.

[edit] References

• IUBMB entry for 2.7.1.105
• BRENDA references for 2.7.1.105 (Recommended.)
• PubMed references for 2.7.1.105
• PubMed Central references for 2.7.1.105
• Google Scholar references for 2.7.1.105
• Van Schaftingen E, Hers HG (1981). "Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP". Biochem. Biophys. Res. Commun. 101: 1078–84. doi:10.1016/0006-291X(81)91859-3. PMID 6458291. 

[edit] External links

The CAS registry number for this enzyme class is 78689-77-7.

• IUBMB entry for 2.7.1.105

• KEGG entry for 2.7.1.105

• BRENDA entry for 2.7.1.105

• NiceZyme view of 2.7.1.105

• EC2PDB: PDB structures for 2.7.1.105

• PRIAM entry for 2.7.1.105

• PUMA2 entry for 2.7.1.105

• IntEnz: Integrated Enzyme entry for 2.7.1.105

• MetaCyc entry for 2.7.1.105

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003873: 6-phosphofructo-2-kinase

• AMIGO entry for GO code 0003873: 6-phosphofructo-2-kinase