6-hydroxynicotinate reductase

From Wikipedia, the free encyclopedia

In enzymology, a 6-hydroxynicotinate reductase (EC 1.3.7.1) is an enzyme that catalyzes the chemical reaction

6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin 6-hydroxynicotinate + reduced ferredoxin

Thus, the two substrates of this enzyme are 6-oxo-1,4,5,6-tetrahydronicotinate and oxidized ferredoxin, whereas its two products are 6-hydroxynicotinate and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase. Other names in common use include 6-oxotetrahydronicotinate dehydrogenase, 6-hydroxynicotinic reductase, HNA reductase, and 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase.

[edit] References

• IUBMB entry for 1.3.7.1
• BRENDA references for 1.3.7.1 (Recommended.)
• PubMed references for 1.3.7.1
• PubMed Central references for 1.3.7.1
• Google Scholar references for 1.3.7.1
• Holcenberg JS, Tsai L (1969). "Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid". J. Biol. Chem. 244: 1204–11. PMID 5767303. 

[edit] External links

The CAS registry number for this enzyme class is 9030-84-6.

• IUBMB entry for 1.3.7.1

• KEGG entry for 1.3.7.1

• BRENDA entry for 1.3.7.1

• NiceZyme view of 1.3.7.1

• EC2PDB: PDB structures for 1.3.7.1

• PRIAM entry for 1.3.7.1

• PUMA2 entry for 1.3.7.1

• IntEnz: Integrated Enzyme entry for 1.3.7.1

• MetaCyc entry for 1.3.7.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047595: 6-hydroxynicotinate reductase

• AMIGO entry for GO code 0047595: 6-hydroxynicotinate reductase