6-hydroxyhexanoate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) is an enzyme that catalyzes the chemical reaction

6-hydroxyhexanoate + NAD⁺ 6-oxohexanoate + NADH + H⁺

Thus, the two substrates of this enzyme are 6-hydroxyhexanoate and NAD⁺, whereas its 3 products are 6-oxohexanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD+ oxidoreductase. This enzyme participates in caprolactam degradation.

[edit] References

• IUBMB entry for 1.1.1.258
• BRENDA references for 1.1.1.258 (Recommended.)
• PubMed references for 1.1.1.258
• PubMed Central references for 1.1.1.258
• Google Scholar references for 1.1.1.258
• Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60: 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261. 
• Hecker LI, Tondeur Y, Farrelly JG (1984). "Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate". Chem. Biol. Interact. 49: 235–48. doi:10.1016/0009-2797(84)90064-4. PMID 6722936. 

[edit] External links

The CAS registry number for this enzyme class is 77000-03-4.

• IUBMB entry for 1.1.1.258

• KEGG entry for 1.1.1.258

• BRENDA entry for 1.1.1.258

• NiceZyme view of 1.1.1.258

• EC2PDB: PDB structures for 1.1.1.258

• PRIAM entry for 1.1.1.258

• PUMA2 entry for 1.1.1.258

• IntEnz: Integrated Enzyme entry for 1.1.1.258

• MetaCyc entry for 1.1.1.258

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018463: 6-hydroxyhexanoate dehydrogenase

• AMIGO entry for GO code 0018463: 6-hydroxyhexanoate dehydrogenase