6,7-dihydropteridine reductase

From Wikipedia, the free encyclopedia

In enzymology, a 6,7-dihydropteridine reductase (EC 1.5.1.34) is an enzyme that catalyzes the chemical reaction

a 5,6,7,8-tetrahydropteridine + NAD(P)+ a 6,7-dihydropteridine + NAD(P)H + H⁺

The 3 substrates of this enzyme are 5,6,7,8-tetrahydropteridine, NAD⁺, and NADP⁺, whereas its 4 products are 6,7-dihydropteridine, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase. Other names in common use include 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide), reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), and 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. This enzyme participates in folate biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1YKI, 1YLR, and 1YLU.

[edit] References

• IUBMB entry for 1.5.1.34
• BRENDA references for 1.5.1.34 (Recommended.)
• PubMed references for 1.5.1.34
• PubMed Central references for 1.5.1.34
• Google Scholar references for 1.5.1.34
• Harano T (1972). "New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin". Insect Biochem. 2: 385–399. doi:10.1016/0020-1790(72)90019-4. 
• Hasegawa H (Tokyo). "Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH". J. Biochem.: 169–77. PMID 191436. 
• Kaufman S (1962). "Phenylalanine hydroxylase". Methods Enzymol. 5: 809–816. 
• Lind KE (1972). "Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines". Eur. J. Biochem. 25: 560–2. doi:10.1111/j.1432-1033.1972.tb01728.x. PMID 4402916. 
• Nakanishi N, Hasegawa H, Watabe S (Tokyo). "A new enzyme, NADPH-dihydropteridine reductase in bovine liver". J. Biochem.: 681–5. PMID 16875. 

[edit] External links

The CAS registry number for this enzyme class is 9074-11-7.

• IUBMB entry for 1.5.1.34

• KEGG entry for 1.5.1.34

• BRENDA entry for 1.5.1.34

• NiceZyme view of 1.5.1.34

• EC2PDB: PDB structures for 1.5.1.34

• PRIAM entry for 1.5.1.34

• PUMA2 entry for 1.5.1.34

• IntEnz: Integrated Enzyme entry for 1.5.1.34

• MetaCyc entry for 1.5.1.34

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004155: 6,7-dihydropteridine reductase

• AMIGO entry for GO code 0004155: 6,7-dihydropteridine reductase