5alpha-hydroxysteroid dehydratase

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In enzymology, a 5alpha-hydroxysteroid dehydratase (EC 4.2.1.62) is an enzyme that catalyzes the chemical reaction

5alpha-ergosta-7,22-diene-3beta,5-diol ergosterol + H₂O

Hence, this enzyme has one substrate, 5alpha-ergosta-7,22-diene-3beta,5-diol, and two products, ergosterol and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming). This enzyme is also called 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase.

[edit] References

• IUBMB entry for 4.2.1.62
• BRENDA references for 4.2.1.62 (Recommended.)
• PubMed references for 4.2.1.62
• PubMed Central references for 4.2.1.62
• Google Scholar references for 4.2.1.62
• Topham RW, Gaylor JL (1970). "Isolation and purification of a 5 alpha-hydroxysterol dehydrase of yeast". J. Biol. Chem. 245: 2319–27. PMID 5442273. 

[edit] External links

The CAS registry number for this enzyme class is 9075-27-8.

• IUBMB entry for 4.2.1.62

• KEGG entry for 4.2.1.62

• BRENDA entry for 4.2.1.62

• NiceZyme view of 4.2.1.62

• EC2PDB: PDB structures for 4.2.1.62

• PRIAM entry for 4.2.1.62

• PUMA2 entry for 4.2.1.62

• IntEnz: Integrated Enzyme entry for 4.2.1.62

• MetaCyc entry for 4.2.1.62

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047587: 5-alpha-hydroxysteroid dehydratase

• AMIGO entry for GO code 0047587: 5-alpha-hydroxysteroid dehydratase