5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

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In enzymology, a 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4.1.1.68) is an enzyme that catalyzes the chemical reaction

5-oxopent-3-ene-1,2,5-tricarboxylate $\rightleftharpoons$ 2-oxohept-3-enedioate + CO₂

Hence, this enzyme has one substrate, 5-oxopent-3-ene-1,2,5-tricarboxylate, and two products, 2-oxohept-3-enedioate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming). Other names in common use include 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase, and 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase. This enzyme participates in tyrosine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1I7O.

[edit] References

IUBMB entry for 4.1.1.68
BRENDA references for 4.1.1.68 (Recommended.)
PubMed references for 4.1.1.68
PubMed Central references for 4.1.1.68
Google Scholar references for 4.1.1.68
Garrido-Pertierra A and Cooper RA (1981). "Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate pathway of Escherichia coli". Eur. J. Biochem. 117: 581–584.