5-HT4 receptor

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The correct title of this article is 5-HT4 receptor. It appears incorrectly here because of technical restrictions.


5-hydroxytryptamine (serotonin) receptor 4
Identifiers
Symbol(s) HTR4; 5-HT4; 5-HT4R
External IDs OMIM: 602164 MGI: 109246 HomoloGene: 20243
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3360 15562
Ensembl ENSG00000164270 ENSMUSG00000026322
Uniprot Q13639 Q3URB5
Refseq NM_000870 (mRNA)
NP_000861 (protein)		 NM_008313 (mRNA)
NP_032339 (protein)
Location Chr 5: 147.81 - 148.01 Mb Chr 18: 62.45 - 62.59 Mb
Pubmed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 4, also known as HTR4, is a human gene.

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined.[1]

[edit] See also


[edit] References

  1. ^ Entrez Gene: HTR4 5-hydroxytryptamine (serotonin) receptor 4.

[edit] Further reading

  • Ullmer C, Schmuck K, Kalkman HO, Lübbert H (1995). "Expression of serotonin receptor mRNAs in blood vessels.". FEBS Lett. 370 (3): 215-21. PMID 7656980. 
  • Blondel O, Vandecasteele G, Gastineau M, et al. (1997). "Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium.". FEBS Lett. 412 (3): 465-74. PMID 9276448. 
  • Van den Wyngaert I, Gommeren W, Verhasselt P, et al. (1997). "Cloning and expression of a human serotonin 5-HT4 receptor cDNA.". J. Neurochem. 69 (5): 1810-9. PMID 9349523. 
  • Claeysen S, Faye P, Sebben M, et al. (1997). "Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.". Neuroreport 8 (15): 3189-96. PMID 9351641. 
  • Claeysen S, Faye P, Sebben M, et al. (1997). "Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization.". Cytogenet. Cell Genet. 78 (2): 133-4. PMID 9371406. 
  • Blondel O, Gastineau M, Dahmoune Y, et al. (1998). "Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.". J. Neurochem. 70 (6): 2252-61. PMID 9603189. 
  • Cichon S, Kesper K, Propping P, Nöthen MM (1998). "Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31-q33).". Mol. Membr. Biol. 15 (2): 75-8. PMID 9724925. 
  • Claeysen S, Sebben M, Becamel C, et al. (1999). "Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.". Mol. Pharmacol. 55 (5): 910-20. PMID 10220570. 
  • Bender E, Pindon A, van Oers I, et al. (2000). "Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.". J. Neurochem. 74 (2): 478-89. PMID 10646498. 
  • Mialet J, Berque-Bestel I, Eftekhari P, et al. (2000). "Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.". Br. J. Pharmacol. 129 (4): 771-81. doi:10.1038/sj.bjp.0703101. PMID 10683202. 
  • Bach T, Syversveen T, Kvingedal AM, et al. (2001). "5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.". Naunyn Schmiedebergs Arch. Pharmacol. 363 (2): 146-60. PMID 11218067. 
  • Medhurst AD, Lezoualc'h F, Fischmeister R, et al. (2001). "Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.". Brain Res. Mol. Brain Res. 90 (2): 125-34. PMID 11406291. 
  • Hiroi T, Hayashi-Kobayashi N, Nagumo S, et al. (2002). "Identification and characterization of the human serotonin-4 receptor gene promoter.". Biochem. Biophys. Res. Commun. 289 (2): 337-44. doi:10.1006/bbrc.2001.5979. PMID 11716477. 
  • Vilaró MT, Doménech T, Palacios JM, Mengod G (2002). "Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants.". Neuropharmacology 42 (1): 60-73. PMID 11750916. 
  • López-Rodríguez ML, Murcia M, Benhamú B, et al. (2002). "Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin.". J. Comput. Aided Mol. Des. 15 (11): 1025-33. PMID 11989623. 
  • Ohtsuki T, Ishiguro H, Detera-Wadleigh SD, et al. (2003). "Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees.". Mol. Psychiatry 7 (9): 954-61. doi:10.1038/sj.mp.4001133. PMID 12399948. 
  • Norum JH, Hart K, Levy FO (2003). "Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).". J. Biol. Chem. 278 (5): 3098-104. doi:10.1074/jbc.M206237200. PMID 12446729. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cartier D, Lihrmann I, Parmentier F, et al. (2003). "Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome.". J. Clin. Endocrinol. Metab. 88 (1): 248-54. PMID 12519861. 
  • Manzke T, Guenther U, Ponimaskin EG, et al. (2003). "5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia.". Science 301 (5630): 226-9. doi:10.1126/science.1084674. PMID 12855812. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened