5-guanidino-2-oxopentanoate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a 5-guanidino-2-oxopentanoate decarboxylase (EC 4.1.1.75) is an enzyme that catalyzes the chemical reaction

5-guanidino-2-oxo-pentanoate 4-guanidinobutanal + CO₂

Hence, this enzyme has one substrate, 5-guanidino-2-oxo-pentanoate, and two products, 4-guanidinobutanal and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-guanidino-2-oxo-pentanoate carboxy-lyase (4-guanidinobutanal-forming). Other names in common use include alpha-ketoarginine decarboxylase, and 2-oxo-5-guanidinopentanoate carboxy-lyase. It has 2 cofactors: thiamin diphosphate, and Divalent cation.

[edit] References

• IUBMB entry for 4.1.1.75
• BRENDA references for 4.1.1.75 (Recommended.)
• PubMed references for 4.1.1.75
• PubMed Central references for 4.1.1.75
• Google Scholar references for 4.1.1.75
• Vanderbilt AS, Gaby NS, Rodwell VW (1975). "Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida". J. Biol. Chem. 250: 5322–9. PMID 237915. 

[edit] External links

The CAS registry number for this enzyme class is 56831-67-5.

• IUBMB entry for 4.1.1.75

• KEGG entry for 4.1.1.75

• BRENDA entry for 4.1.1.75

• NiceZyme view of 4.1.1.75

• EC2PDB: PDB structures for 4.1.1.75

• PRIAM entry for 4.1.1.75

• PUMA2 entry for 4.1.1.75

• IntEnz: Integrated Enzyme entry for 4.1.1.75

• MetaCyc entry for 4.1.1.75

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047435: 5-guanidino-2-oxopentanoate decarboxylase

• AMIGO entry for GO code 0047435: 5-guanidino-2-oxopentanoate decarboxylase