5-formyltetrahydrofolate cyclo-ligase
From Wikipedia, the free encyclopedia
In enzymology, a 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) is an enzyme that catalyzes the chemical reaction
- ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
Thus, the two substrates of this enzyme are ATP and 5-formyltetrahydrofolate, whereas its 3 products are ADP, phosphate, and 5,10-methenyltetrahydrofolate.
This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 5-formyltetrahydrofolate cyclo-ligase (ADP-forming). Other names in common use include 5,10-methenyltetrahydrofolate synthetase, formyltetrahydrofolic cyclodehydrase, and 5-formyltetrahydrofolate cyclodehydrase. This enzyme participates in one carbon pool by folate.
Contents |
[edit] Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1SBQ, 1SOU, 1U3F, 1U3G, and 2JCB.
[edit] References
- IUBMB entry for 6.3.3.2
- BRENDA references for 6.3.3.2 (Recommended.)
- PubMed references for 6.3.3.2
- PubMed Central references for 6.3.3.2
- Google Scholar references for 6.3.3.2
- Greenberg DM, Wynston LK and Nagabhushanan A (1965). "Further studies on N5-formyltetrahydrofolic acid cyclodehydrase". Biochemistry 4: 1872–1878.
[edit] External links
-
- The CAS registry number for this enzyme class is 37318-64-2.
[edit] Gene Ontology (GO) codes
 |
This ligase article is a stub. You can help Wikipedia by expanding it. |
