5-amino-6-(5-phosphoribosylamino)uracil reductase
From Wikipedia, the free encyclopedia
In enzymology, a 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) is an enzyme that catalyzes the chemical reaction
- 5-amino-6-(5-phosphoribitylamino)uracil + NADP+
5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+
Thus, the two substrates of this enzyme are 5-amino-6-(5-phosphoribitylamino)uracil and NADP+, whereas its 3 products are 5-amino-6-(5-phosphoribosylamino)uracil, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase. This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase. This enzyme participates in riboflavin metabolism.
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[edit] Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 2AZN, 2B3Z, 2D5N, 2G6V, 2HXV, 2O7P, and 2OBC.
[edit] References
- IUBMB entry for 1.1.1.193
- BRENDA references for 1.1.1.193 (Recommended.)
- PubMed references for 1.1.1.193
- PubMed Central references for 1.1.1.193
- Google Scholar references for 1.1.1.193
- Burrows RB, Brown GM (1978). "Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin". J. Bacteriol. 136: 657–67. PMID 30756.
[edit] External links
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- The CAS registry number for this enzyme class is 69020-28-6.
[edit] Gene Ontology (GO) codes
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