48-bit
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In computer architecture, 48-bit integers, memory addresses, or other data units are those that are at most 48 bits (6 octets) wide. Also, 48-bit CPU and ALU architectures are those that are based on registers, address buses, or data buses of that size.
The IBM AS/400, in its CISC variants, is a 48-bit addressing system. The address size used in logical block addressing was increased to 48 bits with the introduction of ATA-6.
[edit] Images
In digital images, 48 bits per pixel, or 16 bits per each colour channel (red, green and blue), is used for accurate processing. Such images do not look much better than 24-bit images, but the existence of more shades between colours (65,536 as opposed to 256) means that more operations can be performed on the image without risk of noticeable banding or posterization.