4'-methoxyisoflavone 2'-hydroxylase
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In enzymology, a 4'-methoxyisoflavone 2'-hydroxylase (EC 1.14.13.53) is an enzyme that catalyzes the chemical reaction
- formononetin + NADPH + H+ + O2
2'-hydroxyformononetin + NADP+ + H2O
The 4 substrates of this enzyme are formononetin, NADPH, H+, and O2, whereas its 3 products are 2'-hydroxyformononetin, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating). Other names in common use include isoflavone 2'-monooxygenase (ambiguous), and isoflavone 2'-hydroxylase (ambiguous). This enzyme participates in isoflavonoid biosynthesis. It employs one cofactor, heme.
[edit] References
- IUBMB entry for 1.14.13.53
- BRENDA references for 1.14.13.53 (Recommended.)
- PubMed references for 1.14.13.53
- PubMed Central references for 1.14.13.53
- Google Scholar references for 1.14.13.53
- Hinderer W, Flentje U and Barz W (1987). "Microsomal isoflavone 2'-hydroxylases and 3'-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation". FEBS Lett. 214: 101–106. doi:.
[edit] External links
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- The CAS registry number for this enzyme class is 110183-49-8.
[edit] Gene Ontology (GO) codes
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