4-phytase

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In enzymology, a 4-phytase (EC 3.1.3.26) is an enzyme that catalyzes the chemical reaction

myo-inositol hexakisphosphate + H₂O $\rightleftharpoons$ 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate

Thus, the two substrates of this enzyme are myo-inositol hexakisphosphate and H₂O, whereas its two products are 1D-myo-inositol 1,2,3,4,5-pentakisphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-hexakisphosphate 6-phosphohydrolase. Other names in common use include 6-phytase (name based on 1L-numbering system and not 1D-numbering), phytase, and phytate 6-phosphatase. This enzyme participates in inositol phosphate metabolism.

[edit] References

IUBMB entry for 3.1.3.26
BRENDA references for 3.1.3.26 (Recommended.)
PubMed references for 3.1.3.26
PubMed Central references for 3.1.3.26
Google Scholar references for 3.1.3.26
Johnson LF, Tate ME (1969). "The structure of myo-inositol pentaphosphates". Ann. N. Y. Acad. Sci. 165: 526–32. PMID 4310376.
Tomlinson RV and Ballou CE (1962). "Myoinositol polyphosphate intermediates in the dephosphorylation of phytic acid by phytase". Biochemistry 1: 166–171.
Lim PE, Tate ME (1973). "The phytases. II. Properties of phytase fractions F 1 and F 2 from wheat bran and the myoinositol phosphates produced by fraction F 2". Biochim. Biophys. Acta. 302: 316–28. PMID 4349266.
Cosgrove DJ. "Inositol Phosphates: Their Chemistry, Biochemistry, and Physiology, Elsevier, Amsterdam, 1980".