4-oxalmesaconate hydratase

From Wikipedia, the free encyclopedia

In enzymology, a 4-oxalmesaconate hydratase (EC 4.2.1.83) is an enzyme that catalyzes the chemical reaction

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H₂O

Hence, this enzyme has one substrate, 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate, and two products, (E)-4-oxobut-1-ene-1,2,4-tricarboxylate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]. Other names in common use include 4-carboxy-2-oxohexenedioate hydratase, 4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase, oxalmesaconate hydratase, gamma-oxalmesaconate hydratase, 4-carboxy-2-oxohexenedioate hydratase, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase. This enzyme participates in benzoate degradation via hydroxylation.

[edit] References

• IUBMB entry for 4.2.1.83
• BRENDA references for 4.2.1.83 (Recommended.)
• PubMed references for 4.2.1.83
• PubMed Central references for 4.2.1.83
• Google Scholar references for 4.2.1.83
• Maruyama K (Tokyo). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". J. Biochem.: 557–65. PMID 6841353. 

[edit] External links

The CAS registry number for this enzyme class is 85204-95-1.

• IUBMB entry for 4.2.1.83

• KEGG entry for 4.2.1.83

• BRENDA entry for 4.2.1.83

• NiceZyme view of 4.2.1.83

• EC2PDB: PDB structures for 4.2.1.83

• PRIAM entry for 4.2.1.83

• PUMA2 entry for 4.2.1.83

• IntEnz: Integrated Enzyme entry for 4.2.1.83

• MetaCyc entry for 4.2.1.83

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047584: 4-oxalmesaconate hydratase

• AMIGO entry for GO code 0047584: 4-oxalmesaconate hydratase