4-methyleneglutamate-ammonia ligase

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In enzymology, a 4-methyleneglutamate-ammonia ligase (EC 6.3.1.7) is an enzyme that catalyzes the chemical reaction

ATP + 4-methylene-L-glutamate + NH₃ AMP + diphosphate + 4-methylene-L-glutamine

The 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH₃, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is 4-methylene-L-glutamate:ammonia ligase (AMP-forming). This enzyme is also called 4-methyleneglutamine synthetase. This enzyme participates in c5-branched dibasic acid metabolism.

[edit] References

• IUBMB entry for 6.3.1.7
• BRENDA references for 6.3.1.7 (Recommended.)
• PubMed references for 6.3.1.7
• PubMed Central references for 6.3.1.7
• Google Scholar references for 6.3.1.7
• Winter HC, Su TZ, Dekker EE (1983). "4-methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts". Biochem. Biophys. Res. Commun. 111: 484–9. PMID 6838571. 

[edit] External links

The CAS registry number for this enzyme class is 85537-85-5.

• IUBMB entry for 6.3.1.7

• KEGG entry for 6.3.1.7

• BRENDA entry for 6.3.1.7

• NiceZyme view of 6.3.1.7

• EC2PDB: PDB structures for 6.3.1.7

• PRIAM entry for 6.3.1.7

• PUMA2 entry for 6.3.1.7

• IntEnz: Integrated Enzyme entry for 6.3.1.7

• MetaCyc entry for 6.3.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047581: 4-methyleneglutamate-ammonia ligase

• AMIGO entry for GO code 0047581: 4-methyleneglutamate-ammonia ligase