4-hydroxyproline epimerase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxyproline epimerase (EC 5.1.1.8) is an enzyme that catalyzes the chemical reaction

trans-4-hydroxy-L-proline cis-4-hydroxy-D-proline

Hence, this enzyme has one substrate, trans-4-hydroxy-L-proline, and one product, cis-4-hydroxy-D-proline.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase. Other names in common use include hydroxyproline epimerase, hydroxyproline 2-epimerase, and L-hydroxyproline epimerase. This enzyme participates in arginine and proline metabolism.

[edit] References

• IUBMB entry for 5.1.1.8
• BRENDA references for 5.1.1.8 (Recommended.)
• PubMed references for 5.1.1.8
• PubMed Central references for 5.1.1.8
• Google Scholar references for 5.1.1.8
• Adams E and Norton IL (1964). "Purification and properties of inducible hydroxyproline 2-epimerase from Pseudomonas". J. Biol. Chem. 239: 1525–1535. 

[edit] External links

The CAS registry number for this enzyme class is 9024-23-1.

• IUBMB entry for 5.1.1.8

• KEGG entry for 5.1.1.8

• BRENDA entry for 5.1.1.8

• NiceZyme view of 5.1.1.8

• EC2PDB: PDB structures for 5.1.1.8

• PRIAM entry for 5.1.1.8

• PUMA2 entry for 5.1.1.8

• IntEnz: Integrated Enzyme entry for 5.1.1.8

• MetaCyc entry for 5.1.1.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047580: 4-hydroxyproline epimerase

• AMIGO entry for GO code 0047580: 4-hydroxyproline epimerase