4-hydroxyphenylacetaldehyde dehydrogenase

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In enzymology, a 4-hydroxyphenylacetaldehyde dehydrogenase (EC 1.2.1.53) is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + NAD⁺ + H₂O 4-hydroxyphenylacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-hydroxyphenylacetaldehyde, NAD⁺, and H₂O, whereas its 3 products are 4-hydroxyphenylacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.

[edit] References

• IUBMB entry for 1.2.1.53
• BRENDA references for 1.2.1.53 (Recommended.)
• PubMed references for 1.2.1.53
• PubMed Central references for 1.2.1.53
• Google Scholar references for 1.2.1.53
• Cuskey SM, Peccoraro V, Olsen RH (1987). "Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes". J. Bacteriol. 169: 2398–404. PMID 3034855. 

[edit] External links

The CAS registry number for this enzyme class is 109456-56-6.

• IUBMB entry for 1.2.1.53

• KEGG entry for 1.2.1.53

• BRENDA entry for 1.2.1.53

• NiceZyme view of 1.2.1.53

• EC2PDB: PDB structures for 1.2.1.53

• PRIAM entry for 1.2.1.53

• PUMA2 entry for 1.2.1.53

• IntEnz: Integrated Enzyme entry for 1.2.1.53

• MetaCyc entry for 1.2.1.53

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047106: 4-hydroxyphenylacetaldehyde dehydrogenase

• AMIGO entry for GO code 0047106: 4-hydroxyphenylacetaldehyde dehydrogenase