4-hydroxymuconic-semialdehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxymuconic semialdehyde + NAD⁺ + H₂O maleylacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-hydroxymuconic semialdehyde, NAD⁺, and H₂O, whereas its 3 products are maleylacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation.

[edit] References

• IUBMB entry for 1.2.1.61
• BRENDA references for 1.2.1.61 (Recommended.)
• PubMed references for 1.2.1.61
• PubMed Central references for 1.2.1.61
• Google Scholar references for 1.2.1.61
• Spain JC, Gibson DT (1991). "Pathway for Biodegradation of p-Nitrophenol in a Moraxella sp". Appl. Environ. Microbiol. 57: 812–819. PMID 16348446. 

[edit] External links

• IUBMB entry for 1.2.1.61

• KEGG entry for 1.2.1.61

• BRENDA entry for 1.2.1.61

• NiceZyme view of 1.2.1.61

• EC2PDB: PDB structures for 1.2.1.61

• PRIAM entry for 1.2.1.61

• PUMA2 entry for 1.2.1.61

• IntEnz: Integrated Enzyme entry for 1.2.1.61

• MetaCyc entry for 1.2.1.61

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018481: 4-hydroxymuconic-semialdehyde dehydrogenase

• AMIGO entry for GO code 0018481: 4-hydroxymuconic-semialdehyde dehydrogenase