4-hydroxymandelate oxidase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxymandelate oxidase (EC 1.1.3.19) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O₂ 4-hydroxybenzaldehyde + CO₂ + H₂O₂

Thus, the two substrates of this enzyme are (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate and O₂, whereas its 3 products are 4-hydroxybenzaldehyde, CO₂, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase. This enzyme is also called L-4-hydroxymandelate oxidase (decarboxylating). It has 2 cofactors: FAD, and Manganese.

[edit] References

• IUBMB entry for 1.1.3.19
• BRENDA references for 1.1.3.19 (Recommended.)
• PubMed references for 1.1.3.19
• PubMed Central references for 1.1.3.19
• Google Scholar references for 1.1.3.19
• Bhat SG, Vaidyanathan CS (1976). "Purification and properties of L-4-hydroxymandelate oxidase from Pseudomonas convexa". Eur. J. Biochem. 68: 323–31. doi:10.1111/j.1432-1033.1976.tb10818.x. PMID 976259. 

[edit] External links

The CAS registry number for this enzyme class is 60976-30-9.

• IUBMB entry for 1.1.3.19

• KEGG entry for 1.1.3.19

• BRENDA entry for 1.1.3.19

• NiceZyme view of 1.1.3.19

• EC2PDB: PDB structures for 1.1.3.19

• PRIAM entry for 1.1.3.19

• PUMA2 entry for 1.1.3.19

• IntEnz: Integrated Enzyme entry for 1.1.3.19

• MetaCyc entry for 1.1.3.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047579: 4-hydroxymandelate oxidase

• AMIGO entry for GO code 0047579: 4-hydroxymandelate oxidase